17 Neapolitan Mastiff breeders in the PuppyReports directory — including programs in MO, CA, IN, NC, OH, OK. Every listing connects to a PuppyReports™ Card so families can check the DogFacts before they choose.
Neapolitan Mastiff Puppies for Sale by State
Neapolitan Mastiff puppies in Missouri (3)
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About Neapolitan Mastiff Puppies, Breeders & DogFacts
The Neapolitan Mastiff, originating around Naples, Italy, is a giant Working Group guardian bred to protect property with its massive build and calm, watchful presence. Typically 26-31 inches tall and 110, 150+ pounds, it has a short, dense coat, heavy wrinkles, and loose skin, with a low energy level, strong protective instincts, and a loyal, steady temperament toward family while remaining wary of strangers. Grooming is moderate: they shed lightly but drool heavily, need regular wipe downs and careful cleaning and drying of skin folds, plus weekly brushing and routine nail, ear, and dental care; they are sensitive to heat. Daily, low‑impact exercise and early socialization with firm, gentle training are important, and their size and guarding nature suit experienced owners with space. Common health concerns include hip and elbow dysplasia, eye issues (such as cherry eye and eyelid problems), skin fold infections, bloat, and heart problems; they are not hypoallergenic.
Breed Characteristics
Temperament
Neapolitan Mastiff dogs are known for: Dignified, Watchful, Imposing, Stoic, Wrinkled.
- Dignified
- Watchful
- Imposing
- Stoic
- Wrinkled
Family & Household Compatibility
- Good with children, this breed is generally compatible with kids.
- Other dogs: may need careful introductions; not always dog friendly.
- Cats: strong prey drive may make cohabitation with cats challenging.
Known Health Considerations
Hip dysplasia, elbow dysplasia, cardiomyopathy, cherry eye, bloat, skin fold dermatitis, demodicosis
When researching Neapolitan Mastiff breeders, ask for documentation of health screening on both parents. Ethical breeders test for breed appropriate conditions through OFA, PennHIP, or breed club specified DNA panels before breeding.
Before You Choose a Neapolitan Mastiff Puppy
- Can I see health screening documentation for both parents?
- Are the parents registered with the AKC or relevant breed club?
- What is your return policy if the dog cannot remain in my home?
- Can I visit, meet the parents, and see where the puppies are raised?
- Do you provide a written health guarantee and vaccination records?
Screened Neapolitan Mastiff breeders on PuppyReports have submitted documentation, responded to the platform, and maintain an active PuppyReports™ Card. Research any breeder before you make a commitment.
Featured Ethical Neapolitan Mastiff Breeder
Members of the Canine Ethics Leadership Circle™ who breed Neapolitan Mastiff appear here, submitted health documentation, full record transparency, and a signed Canine Ethics Standard. One breeder per breed.
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About these recommendations. PuppyReports surfaces the basic health screening recommendations for each breed in accordance with the principles established by the Orthopedic Foundation for Animals (OFA) Canine Health Information Center (CHIC) program. The OFA, working with each breed’s primary US parent club, sets the recommended testing list per breed. Recommendations may vary by country and region (US OFA CHIC, European FCI, UK Kennel Club, Australian National Kennel Council, etc.). Always review current requirements with your breed’s parent club for your jurisdiction. Last reviewed: 2026-05-02.
Sources & further reading: American Kennel Club breed information; Orthopedic Foundation for Animals CHIC program (ofa.org/chic programs). Breed data sourced from PuppyReports™ breeds database. Last reviewed: 2026-04-24.