2 Daniff breeders in the PuppyReports directory — including programs in IL. Every listing connects to a PuppyReports™ Card so families can check the DogFacts before they choose.
Daniff Puppies for Sale by State
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About Daniff Puppies, Breeders & DogFacts
The Daniff, a cross between the Great Dane and the Mastiff, is a giant companion dog not recognized by the AKC but registered through designer organizations such as the ACHC and IDCR. Adults typically stand 28-33 inches and weigh 115-190 pounds, carrying a short, dense coat that varies slightly across F1, F1B, and multigen litters and sheds moderately year round. Expect the Great Dane's goofy, people oriented affection paired with the Mastiff's calm, watchful steadiness and slow to mature temperament. Daniffs inherit health concerns from both giant parents (see health panel) and suit experienced owners with spacious homes, secure yards, and budgets ready for large breed care.
Parent Breeds
This is a designer cross combining: Great Dane + Mastiff. As a mixed breed cross, individual puppies may inherit traits from either parent breed in varying degrees. Health testing requirements and temperament expectations should be evaluated for both parent breeds.
Breed Characteristics
Temperament
Daniff dogs are known for: Patient, Calm, Affectionate, Mastiff like, Stately.
- Patient
- Calm
- Affectionate
- Mastiff like
- Stately
Family & Household Compatibility
- Good with children, this breed is generally compatible with kids.
- Good with other dogs, typically sociable with other dogs.
- Good with cats, generally tolerant of cats when properly introduced.
Known Health Considerations
Bloat (GDV), hip dysplasia, cardiomyopathy, osteosarcoma
When researching Daniff breeders, ask for documentation of health screening on both parents. Ethical breeders test for breed appropriate conditions through OFA, PennHIP, or breed club specified DNA panels before breeding.
Before You Choose a Daniff Puppy
- Can I see health screening documentation for both parents?
- Are the parents registered with the AKC or relevant breed club?
- What is your return policy if the dog cannot remain in my home?
- Can I visit, meet the parents, and see where the puppies are raised?
- Do you provide a written health guarantee and vaccination records?
Screened Daniff breeders on PuppyReports have submitted documentation, responded to the platform, and maintain an active PuppyReports™ Card. Research any breeder before you make a commitment.
Featured Ethical Daniff Breeder
Members of the Canine Ethics Leadership Circle™ who breed Daniff appear here, submitted health documentation, full record transparency, and a signed Canine Ethics Standard. One breeder per breed.
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About these recommendations. PuppyReports surfaces the basic health screening recommendations for each breed in accordance with the principles established by the Orthopedic Foundation for Animals (OFA) Canine Health Information Center (CHIC) program. The OFA, working with each breed’s primary US parent club, sets the recommended testing list per breed. Recommendations may vary by country and region (US OFA CHIC, European FCI, UK Kennel Club, Australian National Kennel Council, etc.). Always review current requirements with your breed’s parent club for your jurisdiction. Last reviewed: 2026-05-02.
Sources & further reading: American Kennel Club breed information; Orthopedic Foundation for Animals CHIC program (ofa.org/chic programs). Breed data sourced from PuppyReports™ breeds database. Last reviewed: 2026-04-24.